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Jerome Courcambeck
Drug Discovery | Drug Development | CMC | IP Strategy
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March 20, 2020
"A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19" Cao B. and Others published in New England Journal of Medecine March 18, 2020 DOI: 10.1056/NEJMoa2001282 In this clinical trial, a total of 199 patients with laboratory-confirmed SARS-CoV-2 infection were randomized, 99 were assigned to the lopinavir–ritonavir group, and 100 to the standard-care group. This trial published by Cao B. et al. shows that treatment with lopinavir–ritonavir combination therapy was not associated with a difference from the standard care. https://lnkd.in/gSPdx4y Antiviral potency of the lopinavir-ritonavir combination against covid19 seems not enough highly potent for the selected patients. See Fig 3, SARS-CoV-2 Viral RNA Load by qPCR on Throat Swabs #covid19 #antiviral #covid19therapy #covid19combinationtherapy
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March 20, 2020