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Jerome Courcambeck
Drug Discovery | Drug Development | CMC | IP Strategy
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May 25, 2025
Thanks to Chemical.AI for the design highlights of Elironrasib (RMC-6291) and Daraxonrasib (RMC-6236), both potent and noncovalent inhibitors of the active state of RAS (G12C). Both agents, Elironrasib and Daraxonrasib, from Revolution Medicines, are under clinical investigations in RAS mutant advanced tumors. Elironrasib and Daraxonrasib show how medicinal chemists can be innovative, creative, not afraid of the drug design complexity and pushing the boundaries of the "sometimes" simplified medicinal chemistry rules... These drug design campaigns show how medicinal chemists have to master the whole medicinal chemistry field, such as structural analysis, molecular modeling, assay development (which assay for which readout), PK-PD, ADME and chemical synthesis. A great illustration of the medicinal chemistry Art. Original articles can be found here for a Sunday beach book: Elironrasib (RMC-6291): https://lnkd.in/eycMSYMS Daraxonrasib (RMC-6236) https://lnkd.in/e2t2KwE2
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May 25, 2025